Highlights
Horizontal mitochondrial transfer has been identified in multiple biological contexts, including normal tissue development, physiological homeostasis, tissue repair and regeneration, and a wide range of pathologies.
The origins of horizontal mitochondrial transfer are evident in cell–cell communication systems present in ancestral bacterial and archeal cells that gave rise to complex life.
Horizontal mitochondrial transfer can restore impaired cellular metabolism by supplying functional mitochondria to damaged cells, highlighting its potential as a novel therapeutic strategy for a variety of pathological conditions.
Horizontal mitochondrial transfer in cancer may contribute to metabolic remodeling, tumor progression, immune suppression, therapeutic resistance, and metastasis, indicating that mitochondrial transfer presents a potential target for anticancer therapies.
Horizontal mitochondrial transfer is an emerging field in cell biology with important roles in development, tissue physiology, and disease.
Abstract
The field of horizontal mitochondrial transfer (HMT), also referred to as intercellular mitochondrial transfer, has recently gained momentum due to an increasing number of publications that go well beyond diseases such as cancer. From co-culture experiments to in vivo evidence in mouse cancer models, noncancerous diseases, and normal tissue and organ homeostasis and development, it is becoming increasingly clear that HMT is a fundamental physiological phenomenon broadly relevant to complex organisms. Recent methodological advances, epitomized by ultra-high-resolution microscopy and spatial and single-cell multiomics technologies, allow for research that strongly supports HMT as an emerging area of cell biology.